2,852 research outputs found
How Polarized Have We Become? A Multimodal Classification of Trump Followers and Clinton Followers
Polarization in American politics has been extensively documented and
analyzed for decades, and the phenomenon became all the more apparent during
the 2016 presidential election, where Trump and Clinton depicted two radically
different pictures of America. Inspired by this gaping polarization and the
extensive utilization of Twitter during the 2016 presidential campaign, in this
paper we take the first step in measuring polarization in social media and we
attempt to predict individuals' Twitter following behavior through analyzing
ones' everyday tweets, profile images and posted pictures. As such, we treat
polarization as a classification problem and study to what extent Trump
followers and Clinton followers on Twitter can be distinguished, which in turn
serves as a metric of polarization in general. We apply LSTM to processing
tweet features and we extract visual features using the VGG neural network.
Integrating these two sets of features boosts the overall performance. We are
able to achieve an accuracy of 69%, suggesting that the high degree of
polarization recorded in the literature has started to manifest itself in
social media as well.Comment: 16 pages, SocInfo 2017, 9th International Conference on Social
Informatic
Immune heterogeneity of head and tail pancreatic lymph nodes in non-obese diabetic mice
The pancreatic lymph node is critical to the pathogenesis of autoimmune diabetes, as it constitutes the initial site for the priming of autoreactive T cells. In this study, we compared the histopathology of the head pancreatic lymph node (HPLN) to the tail pancreatic lymph node (TPLN) in NOD mice. HPLNs and TPLNs were harvested from 4 week-, 8 week-, and 12 week-old NOD mice, and their microvasculature, extracellular matrix, and immune cell subsets were characterized. The percentages of B cells and antigen-presenting cells (APCs) were much higher in the HPLN, as compared to the TPLN. Notably, the HPLNs of 12 week-old mice were characterized by greater expansion of high endothelial venules (HEVs) and lymphatic vessels in comparison to the TPLNs. Finally, we observed a higher density of extracellular matrix (ECM) fibers surrounding the lymphatic vasculature in the HPLNs than in the TPLNs. These data for the first time demonstrate that the HPLN possesses a different immune microanatomy and organization from the TPLN. These novel observations unveil a major phenotypic difference between two types of LNs from the same organ and may highlight an independent fundamental role played by each PLN during the establishment of T1D
Weight Loss Improves Cardio-Metabolic and Inflammatory State in Subjects with Metabolic Syndrome
Metabolic syndrome (MetS) is a condition characterized by a constellation of reversible major risk factors for cardiovascular disease (CVD) and type 2 diabetes (T2DM). While it has been widely demonstrated that weight reduction by 5\u201310% decreases CVD and T2DM risk factors, including atherogenic dyslipidemia, on the other hand, its effects on comprehensive serum cytokine profile and endotoxemia are less investigated. Furthermore, the impact of weight loss on these parameters was studied especially in subjects with morbid obesity, often after bariatric surgery; while the studies on the effects of a physiological weight reduction with a balanced hypocaloric diet in overweight and moderately obese subjects showed contradictory results
Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report
Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury
Analysis methods for in-beam PET images in proton therapy treatment verification: a comparison based on Monte Carlo simulations
Background and purpose: In-beam Positron Emission Tomography (PET) is one of
the modalities that can be used for in-vivo non-invasive treatment monitoring
in proton therapy. PET distributions obtained during various treatment sessions
can be compared in order to identify regions that have anatomical changes. The
purpose of this work is to test and compare different analysis methods in the
context of inter-fractional PET image comparison for proton treatment
verification.
Methods: For our study we used the FLUKA Monte Carlo code and artificially
generated CT scans to simulate in-beam PET distributions at different stages
during proton therapy treatment. We compared the Beam-Eye-View method, the
Most-Likely-Shift method, the Voxel-Based-Morphology method and the gamma
evaluation method to compare PET images at the start of treatment, and after a
few weeks of treatment. The results were compared to the CT scan.
Results and conclusions: Three-dimensional methods like VBM and gamma are
preferred above two-dimensional methods like MLS and BEV if much statistics is
available, since the these methods allow to identify the regions with anomalous
activity. The VBM approach has as disadvantage that a larger number of MC
simulations is needed. The gamma analysis has the disadvantage that no clinical
indication exist on tolerance criteria. In terms of calculation time, the BEV
and MLS method are preferred. We recommend to use the four methods together, in
order to best identify the location and cause of the activity changes.Comment: 9 pages, 5 figure
Budget Processes: Theory and Experimental Evidence
This paper studies budget processes, both theoretically and experimentally. We compare the outcomes of bottom-up and top-down budget processes. It is often presumed that a top-down budget process leads to a smaller overall budget than a bottom-up budget process. Ferejohn and Krehbiel (1987) showed theoretically that this need not be the case. We test experimentally the theoretical predictions of their work. The evidence from these experiments lends strong support to their theory, both at the aggregate and the individual subject level
It is Hobbes, not Rousseau:an experiment on voting and redistribution
We perform an experiment which provides a laboratory replica of some
important features of the welfare state. In the experiment, all individuals in a group
decide whether to make a costly effort, which produces a random (independent) outcome
for each one of them. The group members then vote on whether to redistribute
the resulting and commonly known total sum of earnings equally amongst themselves.
This game has two equilibria, if played once. In one of them, all players make
effort and there is little redistribution. In the other one, there is no effort and nothingWe thank Iris Bohnet, Tim Cason, David Cooper, John Duffy, Maia Guell, John Van Huyck and Robin Mason for helpful conversations and encouragement. The comments of the Editor and two referees helped improve the paper. We gratefully acknowledge the financial support from Spain’s Ministry of Science and Innovation under grants CONSOLIDER INGENIO 2010 CSD2006-0016 (all authors), ECO2009-10531 (Cabrales), ECO2008-01768 (Nagel) and the Comunidad de Madrid under grant Excelecon (Cabrales), the Generalitat de Catalunya and the CREA program (Nagel), and project SEJ2007-64340 of Spain’s Ministerio de Educación y Ciencia (Rodríguez Mora).Publicad
X-ray grating interferometry design for the 4D GRAPH-X system
The 4D GRAPH-X (Dynamic GRAting-based PHase contrast x-ray imaging) project aims at developing a prototype of an x-ray grating-based phase-contrast imaging scanner in a laboratory setting, which is based on the Moire single-shot acquisition method in order to be optimized for analysing moving objects (in the specific case, a dynamic thorax phantom), that could evolve into a suitable tool for biomedical applications although it can be extended to other application fields. When designing an x-ray Talbot-Lau interferometer, high visibility and sensitivity are two important figures of merit, strictly related to the performance of the system in obtaining high quality phase contrast and dark-field images. Wave field simulations are performed to optimize the setup specifications and construct a high-resolution and high-sensitivity imaging system. In this work, the design of a dynamic imaging setup using a conventional milli-focus x-ray source is presented. Optimization by wave front simulations leads to a symmetric configuration with 5.25 mu m pitch at third Talbot order and 45 keV design energy. The simulated visibility is about 22%. Results from GATE based Monte Carlo simulations show a 19% transmission percentage of the incoming beam into the detector after passing through all the gratings and the sample. Such results are promising in view of building a system optimized for dynamic imaging
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